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Gong L, Yu L, Gong X, et al

Effect of glutathione infusion on leg arterial circulation, cutaneous microcirculation and pain-free walking distance in patients with peripheral obstructive arterial disease: a randomized, double-blind, placebo-controlled trial

264,265 Chronic hyperglycemia elevates ROS production through multiple pathways, including enhanced glucose oxidation, activation of NADPH oxidases, and dysfunction of the mitochondrial electron transport chain

Statistical analyses were performed using SPSS version 21 (SPSS Inc., Chicago, IL, USA)

When NNMT is inhibited: NAD+ levels rise Mitochondria become more efficient Cells burn more energy, even at rest This effect helps the body shift into a more metabolically active state, making it easier to reduce fat and preserve muscle during weight loss