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Activation of this pathway enhances antioxidant gene expression, offering neuroprotection

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The clinical transition from acute COVID-19 to symptomatic PASC seems to vary between hospitalized and non-hospitalized patients

IGF-1 is a highly anabolic peptide hormone responsible for: Muscle cell proliferation and repair Tendon and ligament regeneration Bone growth Glucose uptake in muscle cells Increased satellite cell activation Oral administration of MK-677 raised serum IGF-1 levels by over 60% in healthy adults without altering cortisol, insulin, or gonadotropin concentrations. Chapman et al., Clinical Pharmacology & Therapeutics This rise in IGF-1 is what leads to muscle growth, improved recovery, and increased physical resilience over time

This method is less precise because it does not deposit the medication near the target nerve root, and the steroid solution is free to spread within the epidural space