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Several technical reasons may explain our distinctive findings, including differences in the microbiome sampling site, the limited n per group, singly housing mice, or the use of highly similar lean, Western, and high-fat diets which systematically exchanged fat content with carbohydrate content

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HbA1c reductions with tirzepatide were dose dependent, ranging from 1.9% to 2.6% ( 20 to 28 mmol/mol) and significantly greater than those achieved by any of the comparators in the studies (Fig

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