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In the SURMOUNT-1 obesity trial, participants the majority of whom were women lost a mean of up to roughly 20% of body weight at the highest dose over 72 weeks, according to the published results (PMID 35658024) and the registered protocol on ClinicalTrials.gov (NCT04184622)

Currently sold under the brand names Alphagan and Brymont (Allergan, Inc., Irvine, CA, USA), brimonidine was patented in 1972 and became commercially available as a glaucoma treatment as an eyedrop formulation containing brimonidine tartrate

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Ubiquinone (Coenzyme Q10): Essential for aerobic respiration, it prevents free radicals interaction with antioxidant molecules in the body (126)