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This is illustrated in a study showing that in LPS-induced macrophages, although the rate of glucose consumed was the same as resting macrophages, the rate of lactate produced was much higher, indicating increased glycolysis while suppressing mitochondrial glucose metabolism (ONeill and Hardie, 2013)

In a second study published in 2022, NAD+ is highlighted for its critical role in cellular energy production in the mitochondria

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