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Methylation imbalance impaired detoxification, neurotransmitter production, and DNA repair

For myocardial tissue with limited cell differentiation and regenerative ability, moderate to severe cardiomyocyte death can result in loss of cardiomyocytes, which cannot fully be regenerated and are subsequently replaced by fibrotic scars, seriously affecting cardiac function and leading to HF

Preclinical studies show that moderate-intensity aerobic exercise, such as walking or cycling, can improve drug delivery to tumors, enhance immune cell infiltration, and potentiate treatment efficacy [83]

Blood 2016 128(22), 2016

Mar 2017;32 Suppl 1:90-93

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