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Drugs Clinic

doi: 10.1126/science.1200094 91

The net result is a shift toward fat oxidation rather than fat storage

diazepam, ethosuximide, lamotrigine, phenytoin) by inhibiting their metabolism or protein binding displacement ( 7.2) Patients stabilized on rufinamide should begin valproate therapy at a low dose, and titrate to clinically effective dose ( 7.2) Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with divalproex sodium extended-release tablets ( 7.2) Topiramate: Hyperammonemia and encephalopathy ( 5.10, 7.3) Cannabidiol: ALT and/or AST elevation ( 7.4) Use In Specific Populations Pregnancy: Divalproex sodium extended-release tablets can cause congenital malformations including neural tube defects, decreased IQ, and neurodevelopmental disorders ( 5.2, 5.3, 8.1) Geriatric: Reduce starting dose

Maturitas 95, 610

Leadbetter, W