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3307-A BETTER UNDERSTANDING THE NATURAL HISTORY OF WILSONS DISEASE THOUGH EXPLANT HISTOLOGY PRELIMINARY ANALYSIS AND EXPERIENCE FROM A UK TERTIARY TRANSPLANT CENTRE James Liu Yin, Deepak Joshi, Marianne Samyn, Varuna Aluvihare, Anil Dhawan, Rosa Miquel and Aftab Ala, King's College Hospital Background: Wilsons disease (WD) is a life changing genetic metabolic condition that can present across many organ systems with devastating presentations e.g

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2013;41:6877 Sun T, Kang YY, Liu J, Zhang YL, Ou LL, Liu XN, et al

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These phosphorylation events drive the swift proteasomal degradation of PDCD4 [83]