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Curr Med Chem

Kumi Smith, M., Jewell, B

The suppression of NMNAT2 skews the homeostatic balance that is maintained by the NMNAT2NAD + SARM1 axis and results in axonal degeneration, an effect that is commonly observed in many neurodegenerative diseases or as a physiological response to nerve injury (Wallerian degeneration) [131,132]

Do not put the cap back on the needle

[] Given this pathophysiological difference, we postulate that combining PRF with perineural MeCbl may provide synergistic therapeutic benefits: MeCbl supports remyelination, nerve regeneration, and suppression of ectopic discharge, potentially enhancing or prolonging PRF-induced neuromodulation