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4c) shows that one lipid (with the head group facing the cytosol) occupies most of the area outside the cleft between TM1 and TM4 of different subunits

10.1164/rccm.201910-1977OC 35 FalkeL

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Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM

217,218,219 Deficiency of Cu could increase the level of total cholesterol, a key factor to increase atherosclerosis risk