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In certain embodiments, the cation of Formula IA is one of: wherein: R 5 is H or NH 2

While generally well-tolerated, some patients may experience nausea, vomiting, constipation, diarrhea, or headache

Zhang L, et al

doi: 10.1001/jama.2012.164487 66

This effect appears to apply also in young patients who are at their most productive years and thus, post-stroke depression can be particularly harmful