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[DOI] [PubMed] [Google Scholar] 38.Day C.P

Environ Health Prev Med 13:102108

Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in mice

Lifestyle factors with GST variants: Stop smoking and avoid second-hand smoke: Studies have linked the GSTM1 null genotype with a 46% increase in the risk of lung cancer in smokers.[ref] Avoid Radon: People with GSTM1 null genotypes are at a 3-fold increased risk of lung cancer with radon exposure.[ref] Access this content: An active subscription is required to access this content

Emerging evidence suggests that A plaques contribute synergistically to disease progression together with oxidative stress, inflammation and mitochondrial dysfunction, while this is less clear in regards to tau pathology (Roy et al., 2023), since A aggregation has been determined as source of oxidative stress (Karapetyan et al., 2022) and oxidative stress has been shown to increase the aggregation of A (Mandal et al., 2022)

Heatmap showing fold change in metabolite levels (log 2 ) of the indicated cell lines relative to the average of those in SLC25A39 knockout cells complemented with SLC25A39 cDNA (middle)