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Furthermore, we also examined if these dual-loaded CN NPs have physicochemical properties favorable for clinical application

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Acetoacetyl-CoA thiolase converts two acetyl-CoA molecules into acetoacetyl-CoA, which is combined with another acetyl-coA and is then converted into the intermediate product beta-hydroxy-methylglutaryl-CoA (HMG-CoA) by the key rate-limiting enzyme HMG-CoA synthase 2 (HMGCS2)

Heart Fail 26, 517

doi: 10.3389/fonc.2025.1642745 Received 07 June 2025 Accepted 22 August 2025 Published 10 September 2025 Volume 15 - 2025 Edited by France Carrier, University of Maryland, United States Reviewed by Ioannis Verginadis, University of Pennsylvania, United States Beatrice DOrsi, National Research Council (CNR), Italy Updates Copyright 2025 Wen, Liu, Zhang, Long, Feng and Zhang

Similarly, sacituzumab govitecan combined with atezolizumab (an anti-PD-L1 ICI) is under investigation in TNBC [199]