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doi: 10.1038/s41368-023-00266-9, 122 RyuE

The damaged DNA fragments after IR are released into the cytoplasm and recognized by cyclic GMP-AMP synthase (cGAS) to synthesize cyclic GMP-AMP (cGAMP), which induces the production of type I interferon (IFN) through the stimulation of STING-TBK1-IRF3 signal axis