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R., Cheng S., et al

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De novo synthesis by GTP cyclohydrolase I BH4 is formed de novo from GTP, via a sequence of enzymatic steps carried out by GTP cyclohydrolase I (GTPCH), 6-pyruvoyl tetrahydropterin synthase (PTPS) and sepiapterin reductase (SR) [15]

Ghorbanpour et al

STK38-deficient cells showed broad suppression of both necroptosis and apoptosis induced by various ligands, including lipopolysaccharide (LPS), Fas ligand (FasL) and TNF-related apoptosis-inducing ligand (TRAIL) (Fig