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As suggested, high doses of methylcobalamin could potentiate the RNA-dependent RNA polymerase (RdRp) activity of SARS-CoV-2 nonstructural protein 12 (NSP12) enzymes, which then reduces the viral infection and severity of COVID-19

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It thereby simultaneously inhibits the proinflammatory and pro-MF effects of TNF- because TNF- not only originates from the heart but can also be targeted to change the pathophysiology of the heart (57)