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VRK2 protects PC cells from ferroptosis by facilitating SLC7A11 trafficking Since SLC7A11-mediated cystine uptake and subsequent biosynthesis of GSH detoxifies phospholipid peroxidation and protects cells from ferroptosis [26], we speculated that VRK2-deficient PC cells, vulnerable to GSH inhibition is associated with ferroptosis

Use prospective cohort designs for better temporal causality and enable linking long-term exposure to chronic outcomes and capture intra-individual variability over time

Proprietary blend 85 mg* of: Glutathione (reduced), N-Acetyl L-Cysteine, Acerola (Malpighia glabra)(fruit)

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Richie, J.P., Nichenametla, S., Neidig, W

For macrophage polarization experiments, cells were then treated with either human recombinant IL-4 (10 ng/mL, Cedarlane Labs, Burlington, ON) or IFN- (10 ng/mL, eBioscience, San Diego, CA) for 48 h