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In recent work, Lopes and colleagues demonstrated that caffeine increased the energy charge and redox state of cortical synaptosomes, suggesting that this effect led to an increase in the glycolytic rate, thereby enhancing astrocyte-synapse lactate transport

However, Epitalon did not prolong the mean lifespan in all groups [84]

Crohns Colitis 10 , 495500 (2016)

Reactive astrocytes protect the CNS by releasing neurotrophic factors (for example, NGF, TGF-, LIF and BDNF) and cytokines that promote neuronal survival and create an anti-inflammatory environment 46,47

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