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doi: 10.1089/ARS.2009.2522 72 AgnelloDLankfordCSBreamJMorinobuAGadinaMOSheaJJet al

Under normal physiological conditions, Keap1, as the substrate adaptor of the E3 ubiquitin ligase complex, maintains intracellular redox balance by promoting the ubiquitination and degradation of Nrf2