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UK prescribers working with existing GLP-1 and dual agonist therapies generally advise patients to: Choose a consistent day of the week for injection and set a reminder Document the time and site of each injection in a diary or app Report any unexpected or worsening symptoms promptly to their GP, specialist, or trial team Not adjust the dose independently dose escalation should always be supervised If you are considering joining a clinical trial involving retatrutide, NIHR Be Part of Research (bepartofresearch.nihr.ac.uk) is the current UK service for identifying registered clinical studies and is the recommended starting point for patients