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Research should be limited to in vitro studies and approved preclinical laboratory models

Its apparent capacity to modulate sleep-wake cycles, stress hormone secretion, and oxidative stress responses within a single nine-amino acid structure makes it a particularly compact and multifunctional subject for laboratory investigation into neuropeptide signaling complexity

This state-dependence makes it distinct from conventional sedatives

Despite promising evidence in preclinical studies, few neurotrophic factors have been tested in clinical trials for TBI

Pharmacology Biochemistry and Behavior, 13(6), 895900