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Excretion Pathways Excretion mechanisms for both peptides remain incompletely characterized: Renal filtration likely represents primary elimination route for peptide fragments Hepatic metabolism may contribute to peptide degradation and clearance No evidence of significant biliary excretion in available studies Pharmacokinetic studies in renal or hepatic impairment models are absent from literature The rapid systemic clearance of both peptides contrasts with prolonged downstream effects on growth hormone and IGF-1, indicating that direct peptide presence is not required for sustained biological activity once pituitary signaling cascades are initiated

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References: Jett L, Lger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP

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Jan 21, 2026 Some researchers see dramatic improvements in body composition within weeks

Intermediate protocol After establishing tolerance with a beginner protocol, researchers may move to standard dosing