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6 Biopsy for routine histopathologic examination is recommended to rule out oral melanoma in patients with melanotic macule on the palate, where malignant melanoma is most prevalent

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While it is important to note that skin pigmentation could be considered objectionable by certain populations, it is not normally considered one of the SAEs outlined by the FDA and ICH E2A/E6 guidelines (142, 143)

A skin punch biopsy may be considered, if practical, before beginning topical treatment for IEC to assess tumour risk and confirm diagnosis

Researchers looking to buy PT-141 for their studies can find it available in various forms such as nasal sprays and subcutaneous injections (e.g., the peptide vial and the PT-141 Pre-mixed Pen 10mg)