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4.2 Taxanes overcoming immunosuppression The first trial addressing PTX monotherapy in Kaposis sarcoma patients with HIV infection consisted of the infusion of 135 mg/m 2 of PTX over 3 h every 3 weeks, which increased at each infusion of around 20 mg/m 2 upon tolerability (granulocyte counts must remain above 1,000 leucocytes/L)

Hormonal effects Temporary changes in hormone levels due to the use of steroid medication, including mood swings, insomnia, or changes in appetite, may occur

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2.4 Glutamine metabolism Glutamine is an amino acid which remarkably modulates immune function in the human body

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