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Vitamin B12 deficiency is a real, treatable condition but the right treatment depends entirely on accurate diagnosis

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NICE-aligned management typically involves: Addressing modifiable risk factors (smoking cessation, weight loss, increased physical activity, alcohol reduction) Optimising management of underlying conditions (diabetes, hypertension, depression) Trial of PDE5 inhibitor therapy Referral to specialist services (urology/andrology) if first-line treatments fail or where structural/neurological/endocrine causes are suspected Consideration of psychosexual therapy where appropriate Men should be reassured that ED is a medical condition with effective treatments, and seeking help through proper channels ensures safety, appropriate investigation of underlying causes, and access to evidence-based therapies

748 Melatonin could improve learning and memory abilities in rats with hypoxic-ischemic brain injury by regulating the AKT/Nrf2/GPX4 signaling pathway