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This cross-efficacy between drugs used for the two conditions may indirectly support the hypothesis of a shared pathogenesis

The major efficacy outcome measure was overall survival and additional efficacy outcome measures were time to disease progression, overall response rate, and response duration

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Serotonin syndrome typically presents with the triad of altered mental status, autonomic hyperarousal, and neuromuscular hyperactivity (hyperreflexia, clonus, tremor), predominantly affecting the lower extremities