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Activation of NPY receptor subtype 1 by [D-His26]NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD

APOE3 mice served as our controls because this allele is the most prevalent APOE isoform in humans and does not affect AD risk (Anonymous, 2024)

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(Rd) likewise increases pyruvate flow to mitochondria, reducing the release of cytochrome c (CytoC) and apoptosis-inducing factor (AIF) from mitochondria, thus maximizing the inhibition of neuronal apoptosis (223)