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When excess hepcidin is transferred to the extracellular space, it inhibits the release of Fe 2+ from the cell, ultimately leading to ferroptosis

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Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

(2020) reported that fibroblasts infiltrating the TME secrete lactate to shape lipid metabolic circuits through histone acetylation, highlighting how carbon flux and acyl-donor dynamics can converge on chromatin remodeling [97]

Creatine supplementation may also play a role in downregulating oxidative stress associated with inflammation [89, 90]

2024 Jul 16];38(9):2132-42