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152,153 A study in 16,572 participants aged 65100 years found that higher frequency of engagement in word or number games was associated with better cognitive performance on tests of memory, numeracy, and verbal fluency both at baseline and after two years

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Furthermore, MDM2 and MDMX, which are negative regulators of P53, have been shown to promote ferroptosis via lipid metabolism mediated by peroxisome proliferator-activated receptor alpha (Venkatesh et al., 2020)

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doi: 10.1016/j.intimp.2022.108966 148 KurataYTanakaTNangakuM