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Evidence supporting a role of domain interaction in mediating apoE4 biology was obtained from in vitro studies in neuronal N2A cells expressing R61T mutated apoE4, which abolishes the domain interaction

ISSN 0013-7227

doi:10.1002/brb3.1633 Cheng-Chung Wei J, Huang HC, Chen WJ, Huang CN, Peng CH, Lin CL

The mediation proportion was calculated by determining the ratio of the indirect effect ( ) to the overall causal impact of the exposures on the outcome, providing insight into the extent to which mediators contributed to the observed associations [37]

Subjects were instructed to ingest one pill per day, ideally with breakfast (675 mg per day, for ~90 days)

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