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Yin X, Knecht DA, Lynes MA

Mechanistically, the adaptor protein containing pleckstrin homology domain (APPL1) orchestrates intracellular signaling cascades via its C-terminal phosphotyrosine-binding (PTB) and coiled-coil (CC) domains, which form critical structural interfaces with the cytoplasmic domains of both adiponectin receptors, thereby mediating the downstream effects of AMPK activation (72)

Lewis JA, Nemke B, Lu Y et al (2024) A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model

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