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The availability of PHGDH inhibitors presents an exciting opportunity for preclinical and clinical trials targeting patients with PHGDH-amplified tumors [38]

Furthermore, HIV can elevate cellular iron levels by utilizing hepcidin-mediated degradation of ferroportin, which in turn enhances HIV transcription, replication, and release [83, 84]

This effect is achieved through the downregulation of ASCT2 expression in MKN-45 and MKN-28 cells [49]

Her passion for her work was evident in every interaction

To investigate how metformin exerted its antioxidant effects, we first examined the expression of Nrf2 and its downstream regulatory protein HO-1 in the chondrocytes exposed to H 2 O 2 , with or without metformin treatment

Mapping the proteo-genomic convergence of human diseases