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Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias

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The abnormal accumulation of pathogenic proteins is considered to be common feature of NDs, these abnormal accumulations can occur in a variety of aggregates, including naturally unfolded monomers, -rich oligomers or fibrils, and stable pathogenic proteins fibrils (Lashuel et al., 2002