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ISMP Medication Safety Alert!, 23(24), 1-4

The BA-mediated neuroprotection was accompanied by the significant upregulation of a crucial cellular pathway particularly related to the antioxidant defense system and cell survival, the PI3K/Akt/Nrf2 signaling pathway, thereby increasing antioxidant enzyme levels (GSH, SOD, CAT) and reducing neuronal death

Upstream iron metabolism genes (such as FPN, TFR1, and DMT1) can influence the occurrence and development of ferroptosis 25,26,27,28 , but how does the downstream pathway change