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N Engl J Med 324:11491155 Convention USP (2007) The United States Pharmacopeia, (USP) 30

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In animal models, TRALI is typically induced by neutrophil priming with intratracheal or intravenous LPS before intravenous infusion of anti-neutrophil/human leukocyte antigen (HLA)/major histocompatibility complex antibodies or aged blood products, resulting in neutrophil sequestration and pulmonary edema [78]

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