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The described algorithm was implemented using the Python programming language (version 3.8.3) and can be found in the provided git repository 56

This hypothesis is not plausible, since even in cells harboring IDH1 R132 or IDH2 R172 mutations, 2KG will still be produced by other pathways including glutamate transamination and dehydrogenation (Fig

Subsequently, some other transcription factors and kinases, including hypoxia-inducible factors (HIFs) and phosphatidylinositol 3-kinase (PI3K), have been discovered to possess redox-sensitive elements that can be regulated by ROS [1,20]

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We diluted the siRNA transfection reagent with serum-free medium according to the reagent instructions to avoid the effect of serum on transfection efficiency