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N Engl J Med (2018) 378(10):9319

Examples of the microenvironmental conditions influencing the dual effects of Nrf2 in cancer include overexpression of the GSTP1 enzyme, Keap1 mutations, loss of heterozygosity, and hypoxia/reoxygenation

A recent study revealed that L-kynurenine can contribute to immune tolerance by inducing lipid peroxidation and ferroptosis in NK cells, ultimately promoting gastric cancer growth in in vivo experiments [201] (Fig

Song, Z., Wang, L., Cao, Y., Liu, Z., Zhang, M., Zhang, Z., Jiang, S., Fan, R., Hao, T., Yang, R., Wang, B., Guan, Z., Zhu, L., Liu, Z., Zhang, S., Zhao, L., Xu, Z., Xu, H., & Dai, G

Additionally, the generation of OH was directly measured by EPR with DMPO as a radical trapping agent