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Because L-Citrulline largely bypasses first-pass liver metabolism, it raises plasma L-Arginine levels more efficiently than direct L-Arginine supplementation, gram for gram - a pharmacokinetic advantage that's driven by growing research interest in this amino acid specifically

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Despite the negative outcomes of these studies, edaravone (Radicava), was recently approved by the USFDA (Takei et al., 2017b