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The disease is highly heritable with gene association studies implicating genes that encode polymorphisms in extracellular matrix (ECM) molecules (e.g., MMP, HSP70, NOS3) or ocular development (the Frizzled related MFRP protein, hepatocyte growth factor HGF)

Disturbances in balance can cause various disease conditions

Peng YX, Chen CZ, Luo D, Yu WJ, Li SP, Xiao Y, Yuan B, Liang S, Yao XR, Kim NH, Jiang H et al (2020) Carnosic acid improves porcine early embryonic development by inhibiting the accumulation of reactive oxygen species

Cabeza-Cabrerizo M, Cardoso A, Minutti CM, Pereira da Costa M, Reis e Sousa C

Our findings thus demonstrate a functional association between cellular respiration and vaccine-induced humoral immunity and suggest potential approaches to enhancing vaccine immunogenicity