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Furthermore, the increased expression of HO-1 in individuals suffering from heart failure serves to mitigate the adverse effects of pathological left ventricular remodeling, diminish myocardial hypertrophy, minimize oxidative stress, and abate inflammatory activation [96]

Int Rev Neurobiol 2009

Conclusion: Management of ICH patients on statins varies widely, underscoring the need for robust research to inform evidence-based recommendations

In hereditary hemochromatosis, downregulation of the cystine-glutamate transporter directly exacerbates ferroptosis-driven liver injury, while N-acetylcysteine supplementation restores glutathione levels and inhibits ferroptotic cell death [54]

Chemosphere 287:131915

Recent studies have indicated that the absence of other amino acids, such as arginine, prevents cysteine depletion from triggering ferroptosis, highlighting the complementary roles of multiple amino acids in modulating iron-death [104]