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High-mobility group box 1 (HMGB1), released from damaged cells, binds to Toll-like receptor 4 (TLR4) on macrophages, triggering NF-B activation and production of pro-inflammatory cytokines such as IL-1 and TNF- (98)

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"We're not sure that the CagriSema is best in class." However, an upcoming REDEFINE-4 study, due for release in early 2026, could provide further color on the drug's efficacy over an extended duration and more flexible dosing something Lontoft said could set it apart