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Epithalon, Melatonin, and Circadian Regulation Because Epithalon is associated with pineal and circadian research, its impact on melatonin-related pathways has received particular attention: Rat studies suggest that Epithalon may influence both synthesis and release of melatonin by modulating AANAT and pCREB-related transcription factors, which play central roles in the melatonin production pathway

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doi: 10.1007/s00248-016-0831-8

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Importantly, beyond neurons, microglia are particularly sensitive to this pathway