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S5A, Fig

Cancer Biol Med (2021) 19(1):5673

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However, when the cells were treated with Olaparib, a PARP inhibitor and Z-VAD, a caspase inhibitor, these observed effects were significantly mitigated, suggesting a potential for controlled therapeutic modulation

GPX4 is an endogenous inhibitor of ferroptosis, an iron-dependent lipid peroxidationinduced cell death [17]

Survivors and those presenting later in life develop progressive hematopoietic, neuroendocrine, and other systemic organ failure (Kearns-Sayre syndrome)