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in 2021 underlined the role of mGluR2 participation in the mechanism of COVID-19 infection and cellular internalisation [23]

doi: 10.1002/eji.202350901 20 CeppelliniRGarottaGMalavasiFTruccoM

Its probable mechanism includes activation of renal AGE-RAGE signaling pathways, decreasing levels of monocyte chemotactic protein-1 (MCP-1) and PKC-A, which consequently reduces the production of slit diaphragm proteins such as nephrin and podocin, thereby mitigating the impact of AGE-mediated DN pathogenesis (Muthenna et al., 2014)