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The relationship between excitotoxicity and ALS can be exemplified by the finding that the cerebrospinal fluid of patients with the disease had three-fold higher concentrations of glutamate, aspartate, N -acetyl-aspartyl glutamate, and N -acetyl aspartate when compared to healthy controls [199]

The condition is increasingly recognized as complex, influenced by genetic, neurobiological, and environmental factors, highlighting the limitations of relying solely on behavioral criteria

This process strengthens the body's stress response mechanisms, leading to increased durability and longevity

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Wang Y, Liu M, Jia X, Yang Q, Du Y