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ERT attenuated oxidative stress and attenuated the structural and transcriptional changes in GLA-mutant human iPSC kidney organoids ERT is a major therapeutic option for patients with Fabry disease that improves Fabry-related symptoms and slows renal damage when started at a relatively early stage 11,12

The following primers were used: ELAVL1 (described above), KGA (described above), GAC (described above), and TBP (5GCACAGGAGCCAAGAGTGAA3 and 5TCACAGGTCCCCACCATATT3)

Ichimura Y, Habuchi T, Tsuchiya N, Wang L, Oyama C et al (2004) Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant

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Zhuang S, Ma Y, Zeng Y, et al

Stability and binding affinity changes relative to the wild type were calculated for all possible single variants with pAcF substitution in nanobodies PV2 and PV3 using Rosetta Cartesian_ddG and Flex_ddG (Fig