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doi: 10.1038/s41419-022-04912-8 42 YangWSKimKJGaschlerMMPatelMShchepinovMSStockwellBR

Their study also confirmed that p62 mediates the degradation of Keap1, as evidenced by in vitro experiments involving p62 knockdown with siRNAs [133]

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There could be back-up systems whereby reactive oxygen species would be attacked by 1 antioxidant as a first line of defense, with escaping molecules handled by a second collection of antioxidants