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Additionally, nutritional deficiencies that sometimes accompany rapid weight lossparticularly iron deficiencycan result in low hemoglobin levels (below 12.5 g/dL for women and 13.0 g/dL for men), another common reason for temporary deferral

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76,77 In summary, disc cells respond to altered loads and osmotic pressures, to DAMPs, MMPs and pro-inflammatory cytokines with the expression of catabolic enzymes, with anabolic healing attempts, and with inflammation resulting in failed healing attempts, damage accumulation and chronic inflammation leading eventually to DD

Without the intrinsic factor, ruminants can experience vitamin B12 deficiency

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Because of its similarity to mannose, 2-DG is also known to interfere with N-linked glycosylation 24,25,26