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A ligand donates one or more pairs of electrons to a metal ion, forming a stable coordination complex

2 Specifically, the authors found that treating cells with the Cu ionophore elesclomol at concentrations as low as 40 nM increased intracellular Cu levels and triggered cuproptosis

At present, the methodology for addressing copper deficiency involves the use of copper ion carriers, which are small molecules that form complexes with copper and facilitate its transport across the cell membrane and into the mitochondria (137)