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Nature 551, 384388

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The eyes were rapidly enucleated, fixed for 2 h in the same solution, and then transferred into a sucrose buffer (30% sucrose in a 0.1 M phosphate buffer) for cryoprotection for 24 h

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Studies have demonstrated that the lifespan of mice with OC is considerably reduced owing to the continuous activity of N1ICD, which leads to the aging of endothelial cells, increased expression of chemokines and the adhesion molecule VCAM1, and facilitates recruitment of neutrophils and invasion of tumors (70,74)

doi: 10.1016/j.biocel.2022.106206 159 ChunJChoiRJKhanSLeeDSKimYCNamYJet al